Non-ribosomal peptide synthetase (NRPS)-encoding products and their biosynthetic logics in Fusarium

Microb Cell Fact. 2024 Mar 27;23(1):93. doi: 10.1186/s12934-024-02378-1.

Abstract

Fungal non-ribosomal peptide synthetase (NRPS)-encoding products play a paramount role in new drug discovery. Fusarium, one of the most common filamentous fungi, is well-known for its biosynthetic potential of NRPS-type compounds with diverse structural motifs and various biological properties. With the continuous improvement and extensive application of bioinformatic tools (e.g., anti-SMASH, NCBI, UniProt), more and more biosynthetic gene clusters (BGCs) of secondary metabolites (SMs) have been identified in Fusarium strains. However, the biosynthetic logics of these SMs have not yet been well investigated till now. With the aim to increase our knowledge of the biosynthetic logics of NPRS-encoding products in Fusarium, this review firstly provides an overview of research advances in elucidating their biosynthetic pathways.

Keywords: Fusarium; Biosynthetic gene cluster; Biosynthetic pathway; Non-ribosomal peptide synthetase-encoding product; Secondary metabolite.

Publication types

  • Review

MeSH terms

  • Biosynthetic Pathways / genetics
  • Computational Biology
  • Fungi / metabolism
  • Fusarium* / genetics
  • Fusarium* / metabolism
  • Multigene Family
  • Peptide Synthases / genetics
  • Peptide Synthases / metabolism

Substances

  • non-ribosomal peptide synthase
  • Peptide Synthases