Objective: The purpose of this research was to determine any connections between the characteristics of oleogels made of beeswax and the impact of mango butter.
Methods: Oleogel was prepared through inverted tube methods, and optimized through oil binding capacity. Other evaluations like bright field and polarized microscopy, Fourier-transform infrared (FTIR) spectroscopy, crystallization kinetics, mechanical study, and X-ray diffractometry (XRD). The drug release kinetic studies and in vitro antibacterial studies were performed.
Results: FTIR study reveals that the gelation process does not significantly alter the chemical composition of the individual components. Prepared gel exhibiting fluid-like behavior or composed of brittle networks is particularly vulnerable to disruptions in their network design. The incorporation of mango butter increases the drug permeation. In-vitro microbial efficacy study was found to be excellent.
Conclusion: The studies revealed that mango butter can be used to modify the physico-chemical properties of the oleogels.
Keywords: Mango butter; Moringa seed oil; antimicrobial efficacy; beeswax oleogel; linezolid; topical infections.