A case of granulomatosis with polyangiitis-associated scleritis presenting as conjunctivitis

Aashna Doshi; Mauli Shah; Bhaskar Srinivasan; Parthopratim Dutta Majumder

doi:10.4103/ojo.ojo_255_22

A case of granulomatosis with polyangiitis-associated scleritis presenting as conjunctivitis

Oman J Ophthalmol. 2024 Feb 21;17(1):127-129. doi: 10.4103/ojo.ojo_255_22. eCollection 2024 Jan-Apr.

Authors

Aashna Doshi¹, Mauli Shah¹, Bhaskar Srinivasan², Parthopratim Dutta Majumder¹

Affiliations

¹ Department of Uvea, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, Tamil Nadu, India.
² Department of Cornea and Ocular Surface, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Abstract

A 42-year-old male presented initially with conjunctivitis and was treated with topical medical medications without any improvement. He developed ocular pain subsequently and further examination revealed lid edema, conjunctival hyperemia with chemosis, matting of lashes with yellowish discharge, and deeper episcleral congestion which did not blanch with topical vasoconstrictor. Subsequent laboratory investigation revealed positive cytoplasmic-antineutrophil cytoplasmic antibody (Anti-PR 3 antibody). He continued to develop recurrences and finally responded to oral azathioprine. Granulomatosis with polyangitis may rarely present as conjunctivitis and subsequently manifest as scleritis.

Keywords: Antineutrophil cytoplasmic antibody; azathioprine; conjunctivitis; granulomatosis with polyangitis; scleritis.

Publication types

Case Reports