The Simplified Thrombo-Inflammatory Score as a Novel Predictor of All-Cause Mortality in Patients with Heart Failure: A Retrospective Cohort Study

Meng-Die Cheng; Ying-Ying Zheng; Xing-Yan Zhang; Tuersun Ruzeguli; Yisimayili Sureya; Yisha Didaer; Mahemuti Ailiman; Jin-Ying Zhang

doi:10.2147/JIR.S452544

The Simplified Thrombo-Inflammatory Score as a Novel Predictor of All-Cause Mortality in Patients with Heart Failure: A Retrospective Cohort Study

J Inflamm Res. 2024 Mar 20:17:1845-1855. doi: 10.2147/JIR.S452544. eCollection 2024.

Authors

Meng-Die Cheng¹, Ying-Ying Zheng², Xing-Yan Zhang², Tuersun Ruzeguli², Yisimayili Sureya², Yisha Didaer², Mahemuti Ailiman², Jin-Ying Zhang¹

Affiliations

¹ Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
² Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, People's Republic of China.

Abstract

Background: The simplified thrombo-inflammatory score (sTIPS) has recently emerged as a novel prognostic score. Hence, we investigated the prognostic value of sTIPS for predicting long-term mortality in patients with heart failure (HF).

Methods: A total of 3741 patients were analyzed in this study. The sTIPS was calculated based on the white blood cell count (WBC) and the mean platelet volume to platelet count (MPV/PC) ratio at admission. The mean follow-up time was 22.75 months. Multivariable Cox regression analyses were used to investigate the associations between the sTIPS and all-cause mortality (ACM).

Results: In the whole study population, multivariate Cox regression analysis showed that patients in both the sTIPS 2 and sTIPS 1 groups had significantly increased risk of ACM as compared with patients in the sTIPS 0 group (hazard ratio [HR]=1.706, 95% confidence interval [CI]: 1.405-2.072, P<0.001 and HR = 1.431, 95% CI 1.270-1.612, P<0.001). The same significant trend was observed in heart failure with preserved ejection fraction (HFpEF) patients (sTIPS1 vs sTIPS0: HR = 1.366, 95% CI 1.100-1.697, P = 0.005; sTIPS2 vs sTIPS0: HR = 1.995, 95% CI 1.460-2.725, P<0.001). However, only sTIPS 1 group had a significantly increased the risk of ACM compared to the sTIPS 0 group among patients with HFmrEF (sTIPS1 vs sTIPS0: HR = 1.648, 95% CI 1.238-2.194, P = 0.001) and HFrEF (sTIPS1 vs sTIPS0: HR = 1.322, 95% CI 1.021-1.712, P = 0.035).

Conclusion: sTIPS is useful in predicting risk for long-term mortality in patients with HF.

Keywords: all-cause mortality; heart failure; prognosis; simplified thrombo-inflammatory score.

Grants and funding

This work was supported by the Natural Science Foundation of Henan Province, National Natural Science Foundation of China, CORFCHDZ- Z, Henan Medical Science and Technique Foundation, (grant number 212300410072, 82000238).