1 Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Barcelona 08025, Spain; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address: jfortea@santpau.cat.
2 Trinity Centre for Ageing and Intellectual Disability, Trinity College Dublin, Dublin, Ireland; Global Brain Health Institute, Trinity College Dublin, University of California San Francisco, Dublin, Ireland.
3 Linda Crnic Institute for Down Syndrome and Department of Pharmacology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
4 Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, USA.