Emerging roles of TBK1 in cancer immunobiology

Alex Miranda; Carl A Shirley; Russell W Jenkins

doi:10.1016/j.trecan.2024.02.007

Emerging roles of TBK1 in cancer immunobiology

Trends Cancer. 2024 Mar 21:S2405-8033(24)00044-X. doi: 10.1016/j.trecan.2024.02.007. Online ahead of print.

Authors

Alex Miranda¹, Carl A Shirley², Russell W Jenkins³

Affiliations

¹ Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
² Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
³ Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: rjenkins@mgh.harvard.edu.

PMID: 38519366
DOI: 10.1016/j.trecan.2024.02.007

Abstract

TANK-binding kinase 1 (TBK1) is a versatile serine/threonine protein kinase with established roles in innate immunity, metabolism, autophagy, cell death, and inflammation. While best known for its role in regulating innate immunity, TBK1 has emerged as a cancer cell-intrinsic immune evasion gene by virtue of its role in modulating cellular responses to inflammatory signals emanating from the immune system. Beyond its effect on cancer cells, TBK1 appears to regulate lymphoid and myeloid cells in the tumor immune microenvironment. In this review, we detail recent advances in our understanding of the tumor-intrinsic and -extrinsic roles and regulation of TBK1 in tumor immunity.

Keywords: RIPK1; TBK1; cell death; immunotherapy.

Publication types

Review

Grants and funding

R37 CA283560/CA/NCI NIH HHS/United States