Hyperuricemia research progress in model construction and traditional Chinese medicine interventions

Hongyan Zhou; Jingyi Yang; Xiaoqing Yuan; Xinyu Song; Xingcai Zhang; Ting Cao; Jiayu Zhang

doi:10.3389/fphar.2024.1294755

Hyperuricemia research progress in model construction and traditional Chinese medicine interventions

Front Pharmacol. 2024 Mar 7:15:1294755. doi: 10.3389/fphar.2024.1294755. eCollection 2024.

Authors

Hongyan Zhou^#^{1

2}, Jingyi Yang^#¹, Xiaoqing Yuan¹, Xinyu Song¹, Xingcai Zhang³, Ting Cao⁴, Jiayu Zhang¹

Affiliations

¹ Institute of Chinese Medicine, Binzhou Medical University, Yantai, Shandong, China.
² School of Pharmacy, University of TCM, Jinan, Shandong, China.
³ World Tea Organization, Cambridge, MA, United States.
⁴ The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

^# Contributed equally.

Abstract

Hyperuricemia (HUA), a severe metabolic disease derived from purine metabolism disorder, will lead to abnormally increased serum uric acid (SUA) levels in the body. Studies have shown that HUA is highly related to gout, hypertension, diabetes, coronary heart disease, chronic kidney diseases, and so on. Traditional Chinese medicine (TCM) shows excellent results in treating HUA because of its unique advantages of multi-metabolites and multi-targets. This article reports on the use of TCM components for uric acid (UA)-lowering activity with excellent efficacy and low side effects based on established HUA models. This work summarizes the advantages and limitations of various HUA disease models for efficacy evaluation. Applications of TCM in HUA treatment have also been discussed in detail. This paper reveals recent research progress on HUA in constructing evaluation models and systematic TCM interventions. It will provide a scientific reference for establishing the HUA model and suggest future TCM-related HUA studies.

Keywords: efficacy evaluation; hyperuricemia; hyperuricemia models; traditional Chinese medicine; urate lowering.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Taishan Young Scholar Program of Shandong [TSQN202103110], the Qingchuang Talents Induction Program of Shandong Higher Education Institution [10073004], the General Program of National Natural Science Foundation of China [82174039], the General Project of Shandong Natural Science Foundation [ZR2020MH371], and the Key Project of TCM Science and Technology in Shandong Province [Z-2022085].