Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer

Jenny Bertholet; Paul-Henry Mackeprang; Hannes A Loebner; Silvan Mueller; Gian Guyer; Daniel Frei; Werner Volken; Olgun Elicin; Daniel M Aebersold; Michael K Fix; Peter Manser

doi:10.1016/j.radonc.2024.110237

Organs-at-risk dose and normal tissue complication probability with dynamic trajectory radiotherapy (DTRT) for head and neck cancer

Radiother Oncol. 2024 Mar 20:195:110237. doi: 10.1016/j.radonc.2024.110237. Online ahead of print.

Affiliations

¹ Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland. Electronic address: jenny.bertholet@insel.ch.
² Division of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.

PMID: 38513960
DOI: 10.1016/j.radonc.2024.110237

Abstract

We compared dynamic trajectory radiotherapy (DTRT) to state-of-the-art volumetric modulated arc therapy (VMAT) for 46 head and neck cancer cases. DTRT had lower dose to salivary glands and swallowing structure, resulting in lower predicted xerostomia and dysphagia compared to VMAT. DTRT is deliverable on C-arm linacs with high dosimetric accuracy.

Keywords: Dynamic trajectory radiotherapy; Head and neck cancer; NTCP; Treatment planning; VMAT.