A sympathetic brake on gut GLP-1 release

Antonio J López-Gambero; Victor Jouque; Daniela Cota

doi:10.1016/j.neuron.2024.02.015

A sympathetic brake on gut GLP-1 release

Neuron. 2024 Mar 20;112(6):865-867. doi: 10.1016/j.neuron.2024.02.015.

Authors

Antonio J López-Gambero¹, Victor Jouque¹, Daniela Cota²

Affiliations

¹ University of Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000 Bordeaux, France.
² University of Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000 Bordeaux, France. Electronic address: daniela.cota@inserm.fr.

PMID: 38513615
DOI: 10.1016/j.neuron.2024.02.015

Abstract

The brain-gut neurocircuitry is proving to be finely involved in a wide range of physiological functions. In this issue of Neuron, Ren et al.¹ show that adrenergic signaling suppresses postprandial glucagon-like peptide 1 (GLP-1) secretion. This, in turn, raises circulating glucose levels and impairs brain glucose uptake and cognitive function.

MeSH terms

Animals
Blood Glucose* / metabolism
Brain* / metabolism
Brain-Gut Axis
Cognition*
Glucagon-Like Peptide 1* / metabolism
Humans
Insulin / metabolism
Intestines* / metabolism
Mice

Substances

Blood Glucose
Glucagon-Like Peptide 1
Insulin