Evaluation of in vitro corrosion behavior and biocompatibility of poly[xylitol-(1,12-dodecanedioate)](PXDD)-HA coated porous iron for bone scaffolds applications

Biotechnol J. 2024 Mar;19(3):e2300464. doi: 10.1002/biot.202300464.

Abstract

The present study evaluates the corrosion behavior of poly[xylitol-(1,12-dodecanedioate)](PXDD)-HA coated porous iron (PXDD140/HA-Fe) and its cell-material interaction aimed for temporary bone scaffold applications. The physicochemical analyses show that the addition of 20 wt.% HA into the PXDD polymers leads to a higher crystallinity and lower surface roughness. The corrosion assessments of the PXDD140/HA-Fe evaluated by electrochemical methods and surface chemistry analysis indicate that HA decelerates Fe corrosion due to a lower hydrolysis rate following lower PXDD content and being more crystalline. The cell viability and cell death mode evaluations of the PXDD140/HA-Fe exhibit favorable biocompatibility as compared to bare Fe and PXDD-Fe scaffolds owing to HA's bioactive properties. Thus, the PXDD140/HA-Fe scaffolds possess the potential to be used as a biodegradable bone implant.

Keywords: cell viability; corrosion; hydroxyapatite; poly[xylitol‐(1,12‐dodecanedioate)](PXDD); porous iron.

MeSH terms

  • Coated Materials, Biocompatible* / chemistry
  • Corrosion
  • Durapatite / chemistry
  • Iron
  • Materials Testing
  • Porosity
  • Xylitol*

Substances

  • Xylitol
  • Coated Materials, Biocompatible
  • Iron
  • Durapatite