Visible-Light-Mediated Synthesis of Thioesters Using Thiocarboxylic Acid as the Dual Reagent

J Org Chem. 2024 Apr 5;89(7):4607-4618. doi: 10.1021/acs.joc.3c02877. Epub 2024 Mar 20.

Abstract

We have developed a visible-light-driven method for thioester synthesis that relies on the unique dual role of thiobenzoic acids as one-electron reducing agents and reactants leading to the formation of sulfur radical species. This synthetic process offers a wide scope, accommodating various thioacid and thiol substrates without the need for a photocatalyst.