SC5D is the sixth enzyme in cholesterol biosynthesis targeted by the E3 ubiquitin ligase MARCHF6

Biochim Biophys Acta Mol Cell Biol Lipids. 2024 May;1869(4):159482. doi: 10.1016/j.bbalip.2024.159482. Epub 2024 Mar 18.

Authors

Nicole M Fenton¹, Lydia Qian¹, Nicola A Scott¹, Eloise G Paine¹, Laura J Sharpe¹, Andrew J Brown²

Affiliations

¹ School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
² School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: aj.brown@unsw.edu.au.

PMID: 38508300
DOI: 10.1016/j.bbalip.2024.159482

No abstract available

Keywords: Cholesterol; E3 ubiquitin ligase; Oxygen; Post-translational regulation.

MeSH terms

Cholesterol*
Oxidoreductases Acting on CH-CH Group Donors*
Ubiquitin-Protein Ligases* / genetics
Ubiquitination

Substances

Ubiquitin-Protein Ligases
lathosterol delta-5-dehydrogenase
Cholesterol
Oxidoreductases Acting on CH-CH Group Donors