Nanographene-Au fine-tuning to intensify plasmonic-resonance of polymeric hybrid bionanosystem for synergistic phototherapy and nerve photobiomodulation

Richa Jaswal; Dinesh Kumar; Abdelrahman I Rezk; Vignesh Krishnamoorthi Kaliannagounder; Chan Hee Park; Kyung Hyun Min

doi:10.1016/j.colsurfb.2024.113820

Nanographene-Au fine-tuning to intensify plasmonic-resonance of polymeric hybrid bionanosystem for synergistic phototherapy and nerve photobiomodulation

Colloids Surf B Biointerfaces. 2024 May:237:113820. doi: 10.1016/j.colsurfb.2024.113820. Epub 2024 Feb 22.

Authors

Richa Jaswal¹, Dinesh Kumar², Abdelrahman I Rezk³, Vignesh Krishnamoorthi Kaliannagounder⁴, Chan Hee Park⁵, Kyung Hyun Min⁶

Affiliations

¹ Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 54896, South Korea; Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, South Korea; Department of Bionanosystem Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, South Korea; School of Pharmacy, Jeonbuk National University, Jeonju 54896, South Korea.
² Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 54896, South Korea; Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, South Korea; Department of Bionanosystem Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, South Korea. Electronic address: dineshkumar@jbnu.ac.kr.
³ Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, South Korea; Department of Physiology, Jeonbuk National University Medical School, Jeonju-si 54907, South Korea.
⁴ School of Engineering, Newcastle University, Newcastle Upon Tyne NE1 7RU, United Kingdom.
⁵ Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 54896, South Korea; Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, South Korea. Electronic address: biochan@jbnu.ac.kr.
⁶ School of Pharmacy, Jeonbuk National University, Jeonju 54896, South Korea; Institute of New Drug Development, Jeonbuk National University, Jeonju 54896, South Korea. Electronic address: khmin1492@jbnu.ac.kr.

PMID: 38502975
DOI: 10.1016/j.colsurfb.2024.113820

Abstract

Here, we report the multi-photo-bioactivity of the plasmonic-nano graphitic coordinated polycaprolactone-based aligned nanofibrous scaffolds-based bionanosystem for photothermal breast and colon cancer therapies and peripheral nerve photobiomodulation. The size-optimized colloidal reduced graphene oxide (nRGO, 180 nm) nanosheets, for enhanced photothermal impact, were surface-functionalized with gold nanospheres (AuNPs) to prepare the nRGO@AuNP monodispersed nano-composite and then doped 2.0 mg of nRGO@AuNP in biocompatible and biodegradable polymer polycaprolactone (PCL) to fabricate the nRGO@AuNP-PCL (2.0 mg) plasmonic aligned nanofibrous scaffolds. More than 90% of cancer cells, breast cancer (MCF-7) as well as colon cancer (CT-26), ablated after 5 min of low NIR (808 nm) laser power (0.72 W/cm²) illumination with nRGO@AuNP-PCL (2.0 mg) aligned nanofibrous scaffolds. Besides, the nRGO@AuNP-PCL (2.0 mg) provided an extraordinary microenvironment for adhesion, nerve growth, proliferation, and differentiation of PC12 and S42 cells which mimics the natural extracellular matrix. The 2.5-fold increase in neurite length was observed with NIR illumination after 3 days whereas 1.7-fold was found without NIR illumination after 7 days in comparison to PCL (pure). The current findings will be useful to provide a new crucial approach for preparing biocompatible multifunctional composite plasmonic nanofibers as a highly efficient distinct platform for photothermal therapies and promising bioimplants to overcome the loss of sensation after cancer surgery through nerve photobiomodulation.

Keywords: Breast and colon cancer; Photobiomodulation; Plasmonic boosting; Polymeric nanofibers; RGO-Au tuning; Synergistic phototherapy.

MeSH terms

Colonic Neoplasms*
Gold / pharmacology
Humans
Low-Level Light Therapy*
Metal Nanoparticles*
Nanofibers*
Phototherapy
Polyesters
Polymers
Tissue Scaffolds
Tumor Microenvironment

Substances

Gold
Polymers
Polyesters