MR-guided percutaneous microwave coagulation of small breast tumors

Ying Ji; Yaoyao Zhuo; Ting Li; Jingge Lian; Zilin Wang; Xinyu Guo; Dexing Kong; Kangan Li

doi:10.1186/s13244-024-01645-4

MR-guided percutaneous microwave coagulation of small breast tumors

Insights Imaging. 2024 Mar 18;15(1):76. doi: 10.1186/s13244-024-01645-4.

Authors

Ying Ji¹, Yaoyao Zhuo², Ting Li³, Jingge Lian¹, Zilin Wang¹, Xinyu Guo¹, Dexing Kong⁴, Kangan Li⁵

Affiliations

¹ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 New Songjiang Road, Shanghai, 201620, China.
² Department of Radiology, Zhongshan Hospital, Fudan University School of Medicine, Shanghai, 200000, China.
³ Department of Radiology, First People's Hospital of Changzhou, Jiangsu, 213003, China.
⁴ School of Mathematical Sciences, Zhejiang University, Zhejiang, 310027, China.
⁵ Department of Radiology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. kangan.li@shsmu.edu.cn.

Abstract

Background: To evaluate the technical success and patient safety of magnetic resonance-guided percutaneous microwave coagulation (MR-guided PMC) for breast malignancies.

Methods: From May 2018 to December 2019, 26 patients with breast tumors measuring 2 cm or less were recruited to participate in a prospective, single-institution clinical study. The primary endpoint of this study was the evaluation of treatment efficacy for each patient. Histochemical staining with α-nicotinamide adenine dinucleotide and reduced (NADH)-diaphorase was used to determine cell viability following and efficacy of PMC. The complications and self-reported sensations from all patients during and after ablation were also assessed. The technical success of the PMC procedure was defined when the area of the NADH-diaphorase negative region fully covered the hematoxylin-eosin (H&E) staining region in the tumor.

Results: All patients had a complete response to ablation with no residual carcinoma on histopathological specimen. The mean energy, ablation duration, and procedure duration per tumor were 36.0 ± 4.2 kJ, 252.9 ± 30.9 S, and 104.2 ± 13.5 min, respectively. During the ablation, 14 patients underwent prolonged ablation time, and 1 patient required adjusting of the antenna position. Eleven patients had feelings of subtle heat or swelling, and 3 patients experienced slight pain. After ablation, one patient took two painkillers because of moderate pain, and no patients had postoperative oozing or other complications after PMC. Induration around the ablation area appeared in 16 patients.

Conclusion: MR-guided PMC of small breast tumors is feasible and could be applied in clinical practice in the future.

Critical relevance statement: MR-guided PMC of small breast tumors is feasible and could be applied in clinical practice in the future.

Key points: • MR-guided PMC of small breast tumors is feasible. • PMC was successfully performed for all patients. • All patients were satisfied with the final cosmetic result.

Keywords: Breast; MR-guided; Microwave ablation; Minimally invasive.

Abstract

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