The role of ncRNAs in depression

Xinchi Luan; Han Xing; Feifei Guo; Weiyi Liu; Yang Jiao; Zhenyu Liu; Xuezhe Wang; Shengli Gao

doi:10.1016/j.heliyon.2024.e27307

The role of ncRNAs in depression

Heliyon. 2024 Mar 6;10(6):e27307. doi: 10.1016/j.heliyon.2024.e27307. eCollection 2024 Mar 30.

Authors

Xinchi Luan^{1

2}, Han Xing^{1

2}, Feifei Guo¹, Weiyi Liu^{1

2}, Yang Jiao^{1

2}, Zhenyu Liu^{1

2}, Xuezhe Wang^{1

2}, Shengli Gao³

Affiliations

¹ Department of Physiology and Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
² Department of Clinical Medicine, Qingdao Medical College, Qingdao University, Qingdao, Shandong, China.
³ Biomedical Center, Qingdao Medical College, Qingdao University, Qingdao, Shandong, China.

Abstract

Depressive disorders have a significant impact on public health, and depression have an unsatisfactory recurrence rate and are challenging to treat. Non-coding RNAs (ncRNAs) are RNAs that do not code protein, which have been shown to be crucial for transcriptional regulation. NcRNAs are important to the onset, progress and treatment of depression because they regulate various physiological functions. This makes them distinctively useful as biomarkers for diagnosing and tracking responses to therapy among individuals with depression. It is important to seek out and summarize the research findings on the impact of ncRNAs on depression since significant advancements have been made in this area recently. Hence, we methodically outlined the findings of published researches on ncRNAs and depression, focusing on microRNAs. Above all, this review aims to improve our understanding of ncRNAs and provide new insights of the diagnosis and treatment of depression.

Keywords: Biomarker; Depression; Mechanism; MicroRNA; NcRNAs.

Publication types

Review