Occurrence of Residual Breast Tumors and Efficacy of MRI in their Detection after Vacuum-assisted Excisional Biopsy

Qun Wei; Qing Zheng; Yifeng Gu; Rongyue Teng; Wenhe Zhao

doi:10.2174/0115734056289252240304113622

Occurrence of Residual Breast Tumors and Efficacy of MRI in their Detection after Vacuum-assisted Excisional Biopsy

Curr Med Imaging. 2024 Mar 15. doi: 10.2174/0115734056289252240304113622. Online ahead of print.

Authors

Qun Wei¹, Qing Zheng¹, Yifeng Gu², Rongyue Teng¹, Wenhe Zhao¹

Affiliations

¹ Department of Surgical Oncology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310016, China.
² The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.

PMID: 38494937
DOI: 10.2174/0115734056289252240304113622

Abstract

Background: Residual breast tumors may remain after vacuum-assisted excisional biopsy (VAEB).

Objective: To determine the incidence of residual breast tumors in patients after VAEB and the efficacy of magnetic resonance imaging (MRI) in detecting these tumors.

Methods: This retrospective analysis examined patients who received VAEB before a diagnosis of breast cancer (BC) at our hospital from 2015 to 2019. The incidence of residual tumors after VAEB was determined by MRI and pathological examination. The diagnostic value of MRI in detecting residual tumors was determined for all patients and different subgroups. Logistic regression analysis was used to identify factors associated with residual tumors.

Results: We examined 147 patients and obtained pathological samples from 146 patients, including 103 (70.5%) with residual tumors and 43 (29.5%) without residual tumors. The MRI examinations demonstrated the complete tumor resection rate was 48.9%. Compared to the pathological results, MRI had a positive predictive value of 77.8%, negative predictive value of 48.8%, specificity of 65.6%, and sensitivity of 60.7%. Further analysis indicated that MRI had moderate accuracies for patients with stage pT-1 (71.9%), stage pTNM-IA (73.1%), and luminal B subtype (78.3%). Binary logistic regression analysis showed that the risk of tumor residue correlated with the pathological stage.

Conclusion: Tumor residue is common after VAEB, and MRI has limited accuracy in detecting these residual tumors. However, for small breast tumors and luminal B subtype BC, MRI had higher accuracy in the detection of residual tumors. The risk of tumor residue is closely associated with the pathological stage.

Keywords: Breast cancer (BC); Magnetic resonance imaging (MRI); Residual tumor; Vacuum-assisted excisional biopsy (VAEB).