From a bimodal to a multi-stage view on trypanosomes' differential RNA editing

Abstract

Significant variations in the abundance of mitochondrial RNA processing proteins and their target RNAs across trypanosome life stages present an opportunity to explore the regulatory mechanisms that drive these changes. Utilizing omics approaches can uncover unconventional targets, aiding our understanding of the parasites' adaptation and enabling targeted interventions for differentiation.

Keywords: RNA editing; RNA editing machinery dynamics; omics approaches in parasite adaptation.