Crosstalk between TPC2 and IP3R regulates Ca2+ signals

Trends Cell Biol. 2024 May;34(5):352-354. doi: 10.1016/j.tcb.2024.03.001. Epub 2024 Mar 16.

Abstract

Calcium (Ca2+) plays a pivotal role in cellular signal transmission by triggering downstream signaling in response to an increase in the cytosolic Ca2+ concentration. Intracellular organelles serve as Ca2+ stores that induce differently shaped Ca2+ signals. We discuss a study by Yuan et al. that investigated the interplay between the lysosomal two-pore channel 2 (TPC2) and endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptors (IP3Rs).

Keywords: IP3R; MITF; TFEB; TPC2; lysosomal Ca(2+).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium Channels* / metabolism
  • Calcium Signaling*
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Inositol 1,4,5-Trisphosphate Receptors* / metabolism
  • Lysosomes / metabolism

Substances

  • Inositol 1,4,5-Trisphosphate Receptors
  • Calcium Channels
  • Calcium