Drug-induced chylothorax as a rare pleural complication in dasatinib therapy for chronic myeloid leukaemia

J R Coll Physicians Edinb. 2024 Mar;54(1):44-47. doi: 10.1177/14782715241237577. Epub 2024 Mar 14.

Abstract

Chylothorax is a lymphatic chylous pleural effusion typically associated with traumatic (iatrogenic, non-iatrogenic) and non-traumatic (infections, malignancy, lymphatic disorders) aetiologies. Drug-induced chylothorax is uncommon and mostly reported in association with BCR-ABL tyrosine kinase inhibitor therapy.

Keywords: chronic myeloid leukaemia; chylothorax; dasatinib-induced chylothorax; pleural effusion; tyrosine kinase inhibitors.

MeSH terms

  • Chylothorax* / chemically induced
  • Dasatinib / adverse effects
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive* / pathology
  • Pleural Effusion* / chemically induced
  • Protein Kinase Inhibitors / adverse effects

Substances

  • Dasatinib
  • Protein Kinase Inhibitors