Navigating the terrain of neutrophil extracellular traps in severe malaria pathogenesis

Maria Saeed; Elizabeth H Aitken; Stephen J Rogerson

doi:10.1016/j.pt.2024.03.001

Navigating the terrain of neutrophil extracellular traps in severe malaria pathogenesis

Trends Parasitol. 2024 Apr;40(4):278-279. doi: 10.1016/j.pt.2024.03.001. Epub 2024 Mar 13.

Authors

Maria Saeed¹, Elizabeth H Aitken², Stephen J Rogerson³

Affiliations

¹ Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
² Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.
³ Department of Infectious Diseases, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia; Department of Medicine, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia. Electronic address: sroger@unimelb.edu.au.

PMID: 38485580
DOI: 10.1016/j.pt.2024.03.001

Abstract

Du, Ren, et al. recently showed in a Plasmodium berghei ANKA (PbA) experimental malaria model that phosphatase of regenerating liver 2 (PRL2) regulates neutrophil extracellular traps (NETs) in severe malaria (SM)-related acute lung injury (ALI). PRL2 deficiency caused SM with ALI in a mouse model by increasing NETs in pulmonary tissue; hydroxychloroquine (HCQ) may ameliorate this.

Keywords: acute lung injury; murine malaria; neutrophil extracellular traps (NETs).

MeSH terms

Acute Lung Injury* / etiology
Acute Lung Injury* / pathology
Animals
Extracellular Traps*
Lung / pathology
Malaria* / complications
Mice
Neutrophils