Carcinogenic mechanisms of virus-associated lymphoma

Ying Zhang; Wei Guo; Zhumei Zhan; Ou Bai

doi:10.3389/fimmu.2024.1361009

Carcinogenic mechanisms of virus-associated lymphoma

Front Immunol. 2024 Feb 28:15:1361009. doi: 10.3389/fimmu.2024.1361009. eCollection 2024.

Authors

Ying Zhang¹, Wei Guo¹, Zhumei Zhan¹, Ou Bai¹

Affiliation

¹ Department of Hematology, The First Hospital of Jilin University, Changchun, Jilin, China.

Abstract

The development of lymphoma is a complex multistep process that integrates numerous experimental findings and clinical data that have not yet yielded a definitive explanation. Studies of oncogenic viruses can help to deepen insight into the pathogenesis of lymphoma, and identifying associations between lymphoma and viruses that are established and unidentified should lead to cellular and pharmacologically targeted antiviral strategies for treating malignant lymphoma. This review focuses on the pathogenesis of lymphomas associated with hepatitis B and C, Epstein-Barr, and human immunodeficiency viruses as well as Kaposi sarcoma-associated herpesvirus to clarify the current status of basic information and recent advances in the development of virus-associated lymphomas.

Keywords: EBV; HBV; HCV; HIV; lymphoma; pathogenesis; virus.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Herpesvirus 8, Human*
Humans
Lymphoma* / etiology
Oncogenic Viruses

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by Department of Science and Technology of Jilin Province (20220402064GH) (20200201591JC).