Predictive value of preoperative platelet count and D-dimer levels for spinal cord injury following acute type a aortic dissection

J Cardiothorac Surg. 2024 Mar 13;19(1):121. doi: 10.1186/s13019-024-02597-y.

Abstract

Background: This study aims to identify the risk factors contributing to spinal cord injury (SCI) following a type A acute aortic dissection (TA-AAD).

Methods: This retrospective study was conducted at a single center and involved 481 patients who received frozen elephant trunk stent implantation for TA-AAD. Additionally, these patients underwent total arch replacement with deep hypothermic circulatory arrest. This study was performed at Fuwai Hospital between September 2016 and April 2020.

Results: The resulting data of the multivariate logistic regression analysis demonstrated that preoperative platelet count (odds ratio [OR] = 0.774) and D-dimer levels (OR = 2.247) could serve as independent predictors for postoperative SCI in patients with TA-AAD.

Conclusion: The findings indicate that preoperative platelet count and D-dimer levels are independent risk factors for postoperative SCI in patients with TA-AAD. This study holds significant clinical implications regarding the prognosis and therapeutic responses for patients with TA-AAD.

Keywords: Acute type a aortic dissection; D-dimer; Platelet; Spinal cord injury.

MeSH terms

  • Aorta, Thoracic / surgery
  • Aortic Aneurysm, Thoracic* / complications
  • Aortic Dissection* / surgery
  • Blood Vessel Prosthesis Implantation* / methods
  • Fibrin Fibrinogen Degradation Products*
  • Humans
  • Platelet Count
  • Retrospective Studies
  • Risk Factors
  • Spinal Cord Injuries* / etiology
  • Treatment Outcome

Substances

  • fibrin fragment D
  • Fibrin Fibrinogen Degradation Products