Short cell cycle duration is a phenotype of human epidermal stem cells

Stem Cell Res Ther. 2024 Mar 13;15(1):76. doi: 10.1186/s13287-024-03670-y.

Abstract

Background: A traditional view is that stem cells (SCs) divide slowly. Meanwhile, both embryonic and pluripotent SCs display a shorter cell cycle duration (CCD) in comparison to more committed progenitors (CPs).

Methods: We examined the in vitro proliferation and cycling behavior of somatic adult human cells using live cell imaging of passage zero keratinocytes and single-cell RNA sequencing.

Results: We found two populations of keratinocytes: those with short CCD and protracted near exponential growth, and those with long CCD and terminal differentiation. Applying the ergodic principle, the comparative numbers of cycling cells in S phase in an enriched population of SCs confirmed a shorter CCD than CPs. Further, analysis of single-cell RNA sequencing of cycling adult human keratinocyte SCs and CPs indicated a shortening of both G1 and G2M phases in the SC.

Conclusions: Contrary to the pervasive paradigm, SCs progress through cell cycle more quickly than more differentiated dividing CPs. Thus, somatic human adult keratinocyte SCs may divide infrequently, but divide rapidly when they divide. Additionally, it was found that SC-like proliferation persisted in vitro.

Keywords: Cell cycle duration; Cell cycle progression; Cell tracking; Differentiation; Keratinocyte; Live cell imaging; Progenitor; Single-cell RNA sequencing; Stem cell; Time-lapse microscopy.

MeSH terms

  • Adult
  • Cell Cycle
  • Cell Differentiation
  • Cell Division
  • Cell Proliferation
  • Humans
  • Keratinocytes / metabolism
  • Phenotype
  • Pluripotent Stem Cells*