Risperidone-Induced Leukoneutropenia: Evidence from a Positive Rechallenge and Review of the Literature

Pharmacopsychiatry. 2024 Mar;57(2):78-81. doi: 10.1055/a-2262-8297. Epub 2024 Mar 12.

Abstract

Antipsychotics can cause hematologic disorders, and they can have life-threatening consequences. Risperidone, less commonly associated with hematologic adverse effects, is an atypical antipsychotic medication used to treat conditions such as schizophrenia, bipolar disorder and irritability associated with autism. While risperidone primarily affects the central nervous system, it can have some hematologic adverse effects, although these are relatively rare. It is crucial to note that these side effects are not common, and most people taking risperidone do not experience hematologic disorders. The reporting of such disorders may be more frequent with clozapine compared to other atypical antipsychotics because clozapine treatment necessitates regular hematological monitoring 1.

Publication types

  • Review

MeSH terms

  • Antipsychotic Agents* / therapeutic use
  • Benzodiazepines / adverse effects
  • Clozapine* / therapeutic use
  • Humans
  • Olanzapine
  • Risperidone / adverse effects

Substances

  • Risperidone
  • Clozapine
  • Olanzapine
  • Benzodiazepines
  • Antipsychotic Agents