Sleep duration and lipid metabolism in patients with diabetes mellitus: from the POWER2DM study

Isabel Perez-Corral; Francisco Gomez-Delgado; Merel M Ruissen; Jose D Torres-Peña; Antonio P Arenas-de Larriva; Jacob K Sont; Albert A de Graaf; Bas S Uitbeijerse; Eelco J P de Koning; Javier Delgado-Lista

doi:10.1007/s41105-022-00403-7

Sleep duration and lipid metabolism in patients with diabetes mellitus: from the POWER2DM study

Sleep Biol Rhythms. 2022 Aug 5;20(4):595-599. doi: 10.1007/s41105-022-00403-7. eCollection 2022 Oct.

Authors

Isabel Perez-Corral^#^{1

2

3

4}, Francisco Gomez-Delgado^#^{1

2

3

4}, Merel M Ruissen⁵, Jose D Torres-Peña^{1

2

3

4}, Antonio P Arenas-de Larriva^{1

2

3

4}, Jacob K Sont⁶, Albert A de Graaf⁷, Bas S Uitbeijerse⁵, Eelco J P de Koning^#⁵, Javier Delgado-Lista^#^{1

2

3

4}

Affiliations

¹ Lipids and Atherosclerosis Unit, Internal Medicine Unit, Reina Sofia University Hospital, Avda. Menendez Pidal, S/N., 14004 Cordoba, Spain.
² Department of Medical and Surgical Sciences, University of Cordoba, 14004 Cordoba, Spain.
³ Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain.
⁴ CIBER Fisiopatologia de La Obesidad Y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain.
⁵ Department of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Zuid-Holland The Netherlands.
⁶ Department of Biomedical Data Sciences, Section Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands.
⁷ Department Risk Analysis for Products in Development, The Netherlands Organization for Applied Scientific Research (TNO), 3508 TA Utrecht, The Netherlands.

^# Contributed equally.

Abstract

This study assesses the association between sleep duration and plasma lipid profiles in people with diabetes mellitus (DM). Sleep duration data were obtained in 91 patients from the POWER2DM study (NCT03588104). The patients were divided in tertiles, based on their sleep duration, and blood samples were obtained at the beginning and after 9 months. Significant differences were found, specifically, patients in Tertile 3 (≥ 7.51 h) showed lower plasma levels of high-density lipoprotein cholesterol HDL-c (p < 0.05), apolipoprotein A1 (apo-A1; p < 0.05) and low HDL-c/apo-A1 ratio (p < 0.05). This study shows that sleep duration is associated with plasma lipid profiles in people with DM.

Keywords: Diabetes mellitus; High-density lipoprotein cholesterol; Lipid metabolism; Sleep duration.

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