The impact of early nutritional support on postoperative wound healing in patients with complex fractures: A meta-analysis review

Int Wound J. 2024 Mar;21(3):e14782. doi: 10.1111/iwj.14782.

Abstract

Complex fractures present significant challenges in orthopaedic surgery, particularly in terms of postoperative wound healing. Nutritional status plays a crucial role in the recovery process, with early nutritional support potentially influencing wound healing outcomes. This meta-analysis aimed to assess the impact of early nutritional interventions on postoperative wound healing and scar formation in patients with complex fractures. From an initial pool of 1742 articles, 7 studies were selected for analysis. The results revealed that preoperative nutritional support significantly improved early wound healing, as indicated by lower REEDA scores (SMD = -14.06, 95% CI: [-16.79, -11.32], p < 0.01) 1 week post-surgery. Furthermore, there was a notable reduction in scar formation, as demonstrated by lower Manchester Scar Scale scores (SMD = -25.03, 95% CI: [-30.32, -19.74], p < 0.01) 3 months post-surgery. These findings highlight the importance of incorporating nutritional strategies into the management of complex fractures to optimize postoperative recovery.

Keywords: complex fractures; early nutritional support; orthopaedic surgery; scar formation; wound healing.

Publication types

  • Meta-Analysis

MeSH terms

  • Cicatrix
  • Fractures, Bone* / surgery
  • Humans
  • Nutritional Support
  • Orthopedic Procedures*
  • Wound Healing