Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system

Bai-Wei Zhao; Ying-Jia Chen; Ruo-Peng Zhang; Yong-Ming Chen; Bo-Wen Huang

doi:10.3748/wjg.v30.i6.607

Angiotensin-converting enzyme 2 alleviates liver fibrosis through the renin-angiotensin system

World J Gastroenterol. 2024 Feb 14;30(6):607-609. doi: 10.3748/wjg.v30.i6.607.

Authors

Bai-Wei Zhao¹, Ying-Jia Chen², Ruo-Peng Zhang¹, Yong-Ming Chen¹, Bo-Wen Huang³

Affiliations

¹ Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, Guangdong Province, China.
² Health Science Center, Peking University, Beijing 100191, China.
³ Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, Guangdong Province, China. huangbw1@sysucc.org.cn.

Abstract

The present letter to the editor is related to the study titled 'Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells'. Angiotensin-converting enzyme 2 can alleviate liver fibrosis by regulating autophagy of hepatic stellate cells and affecting the renin-angiotensin system.

Keywords: Angiotensin 1-7; Angiotensin II; Angiotensin-converting enzyme 2; Hepatic stellate cells; Liver fibrosis; Renin-angiotensin system.

MeSH terms

Angiotensin II / metabolism
Angiotensin-Converting Enzyme 2
Animals
Fibrosis
Hepatic Stellate Cells / metabolism
Liver Cirrhosis
Mice
Peptidyl-Dipeptidase A* / metabolism
Renin-Angiotensin System*

Substances

Angiotensin II
Angiotensin-Converting Enzyme 2
Peptidyl-Dipeptidase A
Ace2 protein, mouse