RNA therapeutics for regenerative medicine

Yen Vy Nguyen Thi; Anh Dao Ngo; Dinh-Toi Chu; Sheng-Che Lin; Chia-Ching Wu

doi:10.1016/bs.pmbts.2023.12.002

RNA therapeutics for regenerative medicine

Prog Mol Biol Transl Sci. 2024:204:163-176. doi: 10.1016/bs.pmbts.2023.12.002. Epub 2024 Jan 24.

Authors

Yen Vy Nguyen Thi¹, Anh Dao Ngo², Dinh-Toi Chu³, Sheng-Che Lin⁴, Chia-Ching Wu⁵

Affiliations

¹ Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam.
² Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam.
³ Center for Biomedicine and Community Health, International School, Vietnam National University, Hanoi, Vietnam; Faculty of Applied Sciences, International School, Vietnam National University, Hanoi, Vietnam; Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: chudinhtoi.hnue@gmail.com.
⁴ Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Division of Plastic and Reconstructive Surgery, Tainan Municipal An-Nan Hospital-China Medical University, Tainan, Taiwan. Electronic address: fredlinkgh@gmail.com.
⁵ Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan; International Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan; Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan. Electronic address: joshccwu@mail.ncku.edu.tw.

PMID: 38458737
DOI: 10.1016/bs.pmbts.2023.12.002

Abstract

It is estimated that millions of people around the world experience various types of tissue injuries every year. Regenerative medicine was born and developed for understanding and application with the aim of replacing affected organs or some cells. The research, manufacture, production, and distribution of RNA in cells have acted as a basic foundation for the development and testing of therapies and treatments that are widely applied in different fields of medicine. Vaccines against COVID-19 are considered one of the brilliant and outstanding successes of RNA therapeutics research. With the characteristics of bio-derived RNA therapeutics, the mechanism of rapid implementation, safe production, and flexibility to create proteins depending on actual requirements. Based on the advantages above in this review, we discuss RNA therapeutics for regenerative medicine, and the types of RNA therapies currently being used for regenerative medicine. The relationship between disease and regenerative medicine is currently being studied or tested in RNA therapeutics. We have also covered the mechanisms of action of RNA therapy for regenerative medicine and some of the limitations in our current understanding of the effects of RNA therapy in this area. Additionally, we have also covered developing RNA therapeutics for regenerative medicine, focusing on RNA therapeutics for regenerative medicine. As a final point, we discuss potential applications for therapeutics for regenerative medicine in the future, as well as their mechanisms.

Keywords: Future medicine; Mechanism; RNA; Regenerative medicine; Therapeutics.

Publication types

Review

MeSH terms

COVID-19 Vaccines
Humans
RNA* / therapeutic use
Regenerative Medicine*

Substances

RNA
COVID-19 Vaccines