Electrical stimulation modulates cell behavior and influences bacterial activity, so highly conductive, antimicrobial hydrogels are suitable for promoting wound healing. In this study, highly conductive and antimicrobial Ti3C2Tx (MXene) hydrogels composed of chitosan and poly(vinyl alcohol) and AgCu- H2PYDC MOF were developed. In PVACS/MOF/MXene (PCMM) hydrogels, the MXene layer acts as an electrical conductor. The electrical conductivity is 0.61 ± 0.01 S·cm-1. PCMM hydrogels modulate cell behavior and provide ES antimicrobial capacity under ES at 1 V. The metal ions of MOF form coordination with chitosan molecules and increase the cross-linking density between chitosan molecules, thus improving the mechanical properties of the hydrogel (tensile strength 0.088 ± 0.04 MPa, elongation at break 233 ± 11 %). The PCMM gels had good biocompatibility. The PCMM hydrogels achieved 100 % antibacterial activity against E. coli and S. aureus for 12 h. 1 V electrical stimulation of PCMM hydrogel accelerated the wound healing process in mice by promoting cell migration and neovascularization, achieving 97 ± 0.4 % wound healing on day 14. The hydrogel dressing PCMM-0.1 with MOF addition of 0.1 % had the best wound healing promoting effect and which is a promising dressing for promoting wound healing and is a therapeutic strategy worth developing.
Keywords: Antibacterial; Chitosan; Cross-linking; Electrical stimulation; MXene; Wound healing.
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