Two effective factors in cancer: Investigating the effect of ncRNAs in cancer and also the effect of nanotherapy in its treatment

Raed Obaid Saleh; Hariadi Yuseran; Sofiene Mansouri; Anaheed Hussein Kareem; Maha Noori Shakir; Mohammed Qasim Alasheqi; Nabiyeva Naima Akhmedovna; Sheraliyeva Intizor Dilmurodovna; Ahmed Alawadi; Ali Alsalamy

doi:10.1016/j.prp.2024.155218

Two effective factors in cancer: Investigating the effect of ncRNAs in cancer and also the effect of nanotherapy in its treatment

Pathol Res Pract. 2024 Apr:256:155218. doi: 10.1016/j.prp.2024.155218. Epub 2024 Feb 17.

Affiliations

¹ Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq.
² Department of Obstetry and Ginecology, Lambung Mangkurat University Banjarmasin, Indonesia. Electronic address: hariadiyuseran@yahoo.com.
³ Department of Biomedical Technology, College of Applied Medical Sciences in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia; University of Tunis El Manar, Higher Institute of Medical Technologies of Tunis, Laboratory of Biophysics and Medical Technologies, Tunis, Tunisia.
⁴ College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq.
⁵ Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
⁶ College of Pharmacy, National University of Science and Technology, Dhi Qar, Iraq.
⁷ Veterinary Scientific Research Institute Tayloq, Samarkand, Uzbekistan.
⁸ Laboratory manager, Veterinary Scientific Research Institute Tayloq, Samarkand, Uzbekistan.
⁹ College of Technical Engineering, the Islamic University, Najaf, Iraq; College of Technical Engineering, the Islamic University of Al Diwaniyah, Iraq; College of Technical Engineering, the Islamic University of Babylon, Iraq.
¹⁰ College of Technical Engineering, Imam Ja'afar Al-Sadiq University, Iraq.

PMID: 38458087
DOI: 10.1016/j.prp.2024.155218

Abstract

Cancer remains one of the most pressing health challenges globally, necessitating ongoing research into innovative therapeutic approaches. This article explores two critical factors influencing cancer: ncRNAs and nanotherapy. The role of ncRNAs, including microRNAs and long non-coding RNAs, in cancer pathogenesis, progression, and treatment resistance is elucidated. Additionally, the potential of nanotherapy, leveraging nanoscale materials for targeted drug delivery and enhanced therapeutic efficacy, is investigated. By comprehensively analyzing the molecular mechanisms underlying ncRNA dysregulation and the promise of nanotherapy in cancer treatment, this article aims to provide valuable insights into novel therapeutic strategies for combating cancer.

Keywords: Cancer; Nanotechnology; Treatment approaches.

Publication types

Review

MeSH terms

Humans
MicroRNAs* / genetics
MicroRNAs* / therapeutic use
Neoplasms* / drug therapy
Neoplasms* / genetics
RNA, Long Noncoding* / genetics
RNA, Untranslated / genetics

Substances

RNA, Untranslated
MicroRNAs
RNA, Long Noncoding