Exceptional anticancer photodynamic properties of [1,4-Bis(3,6,9,12-Tetraoxatridec-1-yloxy)phthalocyaninato]zinc(II)

Abstract

Phthalocyanines have been described as effective photosensitizers for photodynamic therapy and are therefore, being studied for their biomedical applications. The metalation of photosensitizers can improve their photodynamic therapy potential. Here, we focus on the biological properties of [1,4-Bis(3,6,9,12-Tetraoxatridec-1-yloxy)phthalocyaninato]zinc(II) (ZnPc(αEG₄)₂) and demonstrate its exceptional anticancer activity upon light stimulation to kill preferentially cancer cells with a start of efficiency at 10 pM. Indeed, in this work we highlighted the high selectivity of ZnPc(αEG₄)₂ for cancer cells compared with healthy ones and we establish its mechanism of action, enabling us to conclude that ZnPc(αEG₄)₂ could be a powerful tool for cancer therapy.

Keywords: Breast cancer cells; Healthy fibroblasts; Photodynamic therapy; Zinc phthalocyanines.