Neighbourhood Watch: Two-pore-2 channels talking to IP3 receptors

Abstract

The recent elegant study by Y. Yuan and colleagues examined functional relationships between the lysosomal two-pore channels 2 (TPC2) and IP3 receptors (IP3Rs) located in the endoplasmic reticulum [1]. The findings of this study suggest functional coupling of these channels and receptors. The study also describes interesting novel phenomena, which may indicate an additional coupling mechanism.

Keywords: Ca2+; IP3 receptors; NAADP; TPC2-A1-N; Two-pore channels.