Chronic infective arthritis with osteomyelitis of the ankle due to Pseudomonas aeruginosa infection in a middle-age woman: A rare causative pathogen requiring vigilance

Medicine (Baltimore). 2024 Mar 8;103(10):e37344. doi: 10.1097/MD.0000000000037344.

Abstract

Rationale: Pseudomonas aeruginosa-induced septic arthritis is a relatively uncommon phenomenon. It has been documented in children with traumatic wounds, young adults with a history of intravenous drug use, and elderly patients with recent urinary tract infections or surgical procedures.

Patient concerns: Fifty-nine year-old female had no reported risk factors. The patient sought medical attention due to a 6-month history of persistent pain and swelling in her right ankle.

Diagnoses: Magnetic resonance imaging and a 3-phase bone scan revealed findings suggestive of infectious arthritis with concurrent osteomyelitis. Histopathological examination of the synovium suggested chronic synovitis, and synovial tissue culture confirmed the presence of P aeruginosa.

Intervention: Arthroscopic synovectomy and debridement, followed by 6 weeks of targeted antibiotic therapy for P aeruginosa.

Outcomes: Following treatment, the patient experienced successful recovery with no symptom recurrence, although she retained a mild limitation in the range of motion of her ankle.

Lessons: To our knowledge, this is the first reported case of chronic arthritis and osteomyelitis caused by P aeruginosa in a patient without conventional risk factors. This serves as a crucial reminder for clinicians to consider rare causative organisms in patients with chronic arthritis. Targeted therapy is imperative for preventing further irreversible bone damage and long-term morbidity.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Ankle
  • Anti-Bacterial Agents / therapeutic use
  • Arthritis, Infectious* / complications
  • Arthritis, Infectious* / diagnosis
  • Arthritis, Infectious* / drug therapy
  • Child
  • Female
  • Humans
  • Middle Aged
  • Osteomyelitis* / complications
  • Osteomyelitis* / diagnosis
  • Osteomyelitis* / therapy
  • Pseudomonas Infections* / complications
  • Pseudomonas Infections* / diagnosis
  • Pseudomonas Infections* / drug therapy
  • Pseudomonas aeruginosa
  • Tomography, X-Ray Computed
  • Young Adult

Substances

  • Anti-Bacterial Agents