Recent Advances in NHC-Catalyzed Chemoselective Activation of Carbonyl Compounds

Abstract

N-Heterocyclic carbenes (NHCs) catalysts have been employed as effective tools in the development of various reactions, which have made notable contributions in developing diverse reaction modes and generating significant functionalized molecules. This review provides an overview of the recent advancements in the chemo- and regioselective activation of different aldehydes using NHCs, categorized into five parts based on the different activation modes. A brief conclusion and outlook is provided to stimulate the development of novel activation modes for accessing functional molecules.

Keywords: N-heterocyclic carbenes (NHCs); activation modes; aldehydes; chemo-and regioselective.