LINC01134: a pivotal oncogene with promising predictive maker and therapeutic target in hepatocellular carcinoma

Front Oncol. 2024 Feb 21:14:1265762. doi: 10.3389/fonc.2024.1265762. eCollection 2024.

Abstract

Hepatocellular carcinoma (HCC) represents a leading and fatal malignancy within the gastrointestinal tract. Recent advancements highlight the pivotal role of long non-coding RNAs (lncRNAs) in diverse biological pathways and pathologies, particularly in tumorigenesis. LINC01134, a particular lncRNA, has attracted considerable attention due to its oncogenic potential in hepatoma. Current research underscores LINC01134's potential in augmenting the onset and progression of HCC, with notable implications in drug resistance. This review comprehensively explores the molecular functions and regulatory mechanisms of LINC01134 in HCC, offering a fresh perspective for therapeutic interventions. By delving into LINC01134's multifaceted roles, we aim to foster novel strategies in HCC management.

Keywords: LINC01134; hepatocellular carcinoma; therapeutic target; tumor biomarker; tumorigenesis.

Publication types

  • Review

Grants and funding

The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.