LncRNA-mediated cartilage homeostasis in osteoarthritis: a narrative review

Li Zhang; Hejin Zhang; Qian Xie; Haiqi Feng; Haoying Li; Zelin Li; Kangping Yang; Jiatong Ding; Guicheng Gao

doi:10.3389/fmed.2024.1326843

LncRNA-mediated cartilage homeostasis in osteoarthritis: a narrative review

Front Med (Lausanne). 2024 Feb 21:11:1326843. doi: 10.3389/fmed.2024.1326843. eCollection 2024.

Authors

Li Zhang^#^{1

2}, Hejin Zhang^#³, Qian Xie^#⁴, Haiqi Feng⁵, Haoying Li⁵, Zelin Li², Kangping Yang^{1

3}, Jiatong Ding^{1

3}, Guicheng Gao¹

Affiliations

¹ Department of Orthopedics, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
² The First Clinical Medicine School, Nanchang University, Nanchang, China.
³ The Second Clinical Medicine School, Nanchang University, Nanchang, China.
⁴ The Third Clinical Medicine School, Nanchang University, Nanchang, China.
⁵ Queen Mary School, Nanchang University, Nanchang, China.

^# Contributed equally.

Abstract

Osteoarthritis (OA) is a degenerative disease of cartilage that affects the quality of life and has increased in morbidity and mortality in recent years. Cartilage homeostasis and dysregulation are thought to be important mechanisms involved in the development of OA. Many studies suggest that lncRNAs are involved in cartilage homeostasis in OA and that lncRNAs can be used to diagnose or treat OA. Among the existing therapeutic regimens, lncRNAs are involved in drug-and nondrug-mediated therapeutic mechanisms and are expected to improve the mechanism of adverse effects or drug resistance. Moreover, targeted lncRNA therapy may also prevent or treat OA. The purpose of this review is to summarize the links between lncRNAs and cartilage homeostasis in OA. In addition, we review the potential applications of lncRNAs at multiple levels of adjuvant and targeted therapies. This review highlights that targeting lncRNAs may be a novel therapeutic strategy for improving and modulating cartilage homeostasis in OA patients.

Keywords: cartilage; cartilage homeostasis; lncRNA; osteoarthritis; targeted therapy.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The present study was supported by the Science and Technology Program of the Jiangxi Educational Commission (grant no. GJJ200246).