Organoids and organ-on-chip technology for investigating host-microorganism interactions

Remigiusz Walocha; MinHee Kim; Jérôme Wong-Ng; Samy Gobaa; Nathalie Sauvonnet

doi:10.1016/j.micinf.2024.105319

Organoids and organ-on-chip technology for investigating host-microorganism interactions

Microbes Infect. 2024 Mar 4:105319. doi: 10.1016/j.micinf.2024.105319. Online ahead of print.

Authors

Remigiusz Walocha¹, MinHee Kim², Jérôme Wong-Ng², Samy Gobaa², Nathalie Sauvonnet³

Affiliations

¹ Tissue Homeostasis Group, Biomaterials and Microfluidics Core Facility, Institut Pasteur, Université Paris Cité, Paris, France; Biomaterials and Microfluidics Core Facility, Institut Pasteur, Université Paris Cité, Paris, France.
² Biomaterials and Microfluidics Core Facility, Institut Pasteur, Université Paris Cité, Paris, France.
³ Tissue Homeostasis Group, Biomaterials and Microfluidics Core Facility, Institut Pasteur, Université Paris Cité, Paris, France; Biomaterials and Microfluidics Core Facility, Institut Pasteur, Université Paris Cité, Paris, France. Electronic address: nathalie.sauvonnet@pasteur.fr.

PMID: 38447861
DOI: 10.1016/j.micinf.2024.105319

Abstract

Recent advances in organoid and organ-on-chip (OoC) technologies offer an unprecedented level of tissue mimicry. These models can recapitulate the diversity of cellular composition, 3D organization, and mechanical stimulation. These approaches are intensively used to understand complex diseases. This review focuses on the latest advances in this field to study host-microorganism interactions.

Keywords: Host-pathogen interaction; Infection; Microphysiological; Organ-on-a-chip; Organoid; Tissue mechanics.