Universal Fasting Glucose Screening Before Gastric Emptying Scintigraphy and the High Prevalence of Undiagnosed Diabetes and Prediabetes

J Nucl Med Technol. 2024 Mar 5;52(1):52-54. doi: 10.2967/jnmt.123.266808.

Abstract

The aim of this study was to assess the rates of undiagnosed diabetes mellitus (DM) and pre-DM in patients undergoing gastric emptying scintigraphy (GES). Diabetes is an epidemic in the United States, and the disease is associated with altered gut motility. As a result, we suspected that a significant number of patients referred for GES may have undiagnosed DM or pre-DM. Given that established procedure standards for GES require all patients to prepare with an 8-h fast, an opportunity is provided to measure the fasting blood glucose (FBG) in all individuals before they undergo the examination. Methods: The charts of patients undergoing GES were reviewed for a history of DM and correlated with FBG and GES results. FBG values, obtained by point-of-care testing, were categorized as normal, pre-DM, or DM. Results: Patients with known DM made up 23% of those referred for GES, and most (55%) had a normal FBG. In those without a history of DM, there were a significant number with undiagnosed pre-DM (12%) and DM (33%). Conclusion: Our study provides the first measure of the likely prevalence of undiagnosed DM and pre-DM and characterizes the different gastric emptying patterns among patients with normal FBG, likely undiagnosed pre-DM, likely undiagnosed DM, and known DM.

Keywords: diabetes; fasting plasma glucose; gastric emptying scintigraphy; gastroparesis; prediabetes; quality assurance.

MeSH terms

  • Diabetes Mellitus* / diagnostic imaging
  • Diabetes Mellitus* / epidemiology
  • Fasting
  • Gastric Emptying
  • Glucose
  • Humans
  • Prediabetic State* / diagnostic imaging
  • Prediabetic State* / epidemiology
  • Prevalence
  • Radionuclide Imaging

Substances

  • Glucose