Comparative Evaluation of Efficacy of Platelet Rich Plasma (PRP) and Platelet Rich Fibrin (PRF) in Bone Regeneration after Surgical Removal of Impacted Bilateral Mandibular Third Molars - A Comparative Study

Vikrant Dilip Sane; Vivek Sunil Nair; Rohit Jadhav; Rashmi Sane; Pankaj Kadam; Rupali Patil

doi:10.1007/s12070-023-04285-0

Comparative Evaluation of Efficacy of Platelet Rich Plasma (PRP) and Platelet Rich Fibrin (PRF) in Bone Regeneration after Surgical Removal of Impacted Bilateral Mandibular Third Molars - A Comparative Study

Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):811-818. doi: 10.1007/s12070-023-04285-0. Epub 2023 Oct 24.

Authors

Vikrant Dilip Sane¹, Vivek Sunil Nair¹, Rohit Jadhav², Rashmi Sane³, Pankaj Kadam⁴, Rupali Patil⁴

Affiliations

¹ Department of OMFS; Bharati Vidyapeeth (Deemed to be), University Dental College and Hospital, Katraj, Pune India.
² Department of ENT; Bharati Vidyapeeth (Deemed to be), University Medical College and Hospital, Katraj, Pune India.
³ Department of Oral Medicine and Radiology; Bharati Vidyapeeth (Deemed to be), University Dental College and Hospital, Katraj, Pune India.
⁴ Department of Prosthodontics, Crown and Bridge; Bharati Vidyapeeth (Deemed to be), University Dental College and Hospital, Katraj, Pune India.

PMID: 38440518
PMCID: PMC10908979 (available on 2025-02-01)
DOI: 10.1007/s12070-023-04285-0

Abstract

Aims and Objectives: To compare the efficacy of platelet rich plasma (PRP) and platelet rich fibrin (PRF) in bone regeneration after removal of impacted bilateral third molars. Materials and Methods: The study was carried out as an open clinical trial on 20 patients chosen from the ones referred to the department of Oral & Maxillofacial Surgery for surgical removal of bilateral mandibular third molar. Patients were prepared for surgical procedure, Inferior alveolar nerve block given using 2% lignocaine hydrochloride with 1:2,00,000 adrenaline. Third molar were removed by flap reflection and bone drilling. Finally, PRF in lower left mandibular third molar region and PRP in lower right mandibular third molar region was inserted and wound closure was done. Cone bean computer tomography (CBCT) was made on 1st postoperative day and 4 months after surgery to evaluate alveolar bone height and density. Result: Alveolar bone height and bone density at post-operative 1st day and 4 months were compared between PRP and PRF group. The bone density and bone volume were analyzed, and there was no significant difference between bone density in PRP and PRF at day 1 and 4th month. Conclusion: As per our study and evaluation, in our postoperative follow up there was no statistically significant differences in bone regeneration by placement of PRP and PRF in extracted socket of third molar. Thus, with this study we can conclude that PRF, would be a good option to Oral and Maxillofacial Surgeons in the near future due to ease of extraction.

Keywords: Cone beam computed tomography; Impacted mandibular third molar; Platelet rich fibrin; Platelet rich plasma.

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