Pediatric acute liver failure (PALF) is a rare and rapidly progressive clinical syndrome with a poor prognosis and significant mortality. The etiology of PALF is complex, and it presents with diverse and atypical clinical manifestations. Accurate diagnosis based on age-related factors, early recognition or prevention of hepatic encephalopathy, and precise supportive treatment targeting the underlying cause are crucial for improving outcomes and prognosis. This article provides a comprehensive review of recent research on the diagnosis and treatment of PALF, aiming to offer guidance for clinical practice.
儿童急性肝衰竭（pediatric acute liver failure, PALF）是一种罕见、病情进展迅速的临床综合征，预后较差，病死率非常高。PALF病因复杂，临床表现多样且不典型，基于年龄的病因诊断、肝性脑病的早期识别、预防及精准的对因支持治疗对改善结局和预后至关重要。该文主要总结PALF诊断及治疗的相关进展，以期为临床工作提供帮助。.
Keywords: Acute liver failure; Child; Diagnosis; Treatment.