Access to CF2COR-Containing Quinazolinones via Visible-Light-Induced Domino Difluoroalkylation/Cyclization of N-Cyanamide Alkenes

Yangyang Cui; Wen Xu; Wenchao Yang; Fei Meng

doi:10.1021/acs.orglett.4c00457

Access to CF₂COR-Containing Quinazolinones via Visible-Light-Induced Domino Difluoroalkylation/Cyclization of N-Cyanamide Alkenes

Org Lett. 2024 Mar 15;26(10):2119-2123. doi: 10.1021/acs.orglett.4c00457. Epub 2024 Mar 4.

Authors

Yangyang Cui¹, Wen Xu¹, Wenchao Yang¹, Fei Meng¹

Affiliation

¹ Institute of Pesticide, College of Plant Protection, Yangzhou University, Yangzhou 225009, China.

PMID: 38436251
DOI: 10.1021/acs.orglett.4c00457

Abstract

A green and highly efficient visible-light-induced radical cascade difluoroalkylation/cyclization reaction of N-cyanamide alkenes has been developed. A variety of CF₂COR-containing quinazolinones have been obtained in high yields with cheap non-metallic 4CzIPN as the photocatalyst. This photocatalytic reaction provides rapid, facile, and practical access to valuable polycyclic quinazolinone, and it is amenable to the gram scale.