PIDA/I2-mediated photo-induced aerobic N-acylation of sulfoximines with methylarenes

Nikita Chakraborty; Kamal K Rajbongshi; Amisha Gondaliya; Bhisma K Patel

doi:10.1039/d4ob00175c

PIDA/I₂-mediated photo-induced aerobic N-acylation of sulfoximines with methylarenes

Org Biomol Chem. 2024 Mar 20;22(12):2375-2379. doi: 10.1039/d4ob00175c.

Authors

Nikita Chakraborty¹, Kamal K Rajbongshi^{1

2}, Amisha Gondaliya³, Bhisma K Patel¹

Affiliations

¹ Department of Chemistry, Indian Institute of Technology Guwahati, 781039, Assam, India. patel@iitg.ac.in.
² Department of Chemistry, Cotton University, Guwahati, 781001, Assam, India.
³ Department of Chemistry, Indrashil University, Kadi, Rajpur, 382740, Gujarat, India.

PMID: 38436055
DOI: 10.1039/d4ob00175c

Abstract

A visible-light-promoted, PIDA/I₂-mediated acylation of NH-sulfoximines with methylarenes as an acyl source has been achieved. This transition metal and photosensitizer-free approach provides easy access to N-acylsulfoximines via oxidative coupling of sulfoximines with easily available methylarenes without using any peroxide source. Mechanistic investigations suggest the intermediacy of radicals and the importance of molecular oxygen.