Necrotizing pancreatitis with invasive candidiasis and candidemia due to Candida albicans and pan-echinocandin-resistant Candidaglabrata

Laman Rahimli; Jon Salmanton-García; Philipp Kasper; Michaela Simon; Oliver A Cornely; Jannik Stemler

doi:10.1016/j.mmcr.2024.100636

Necrotizing pancreatitis with invasive candidiasis and candidemia due to Candida albicans and pan-echinocandin-resistant Candidaglabrata

Med Mycol Case Rep. 2024 Feb 20:43:100636. doi: 10.1016/j.mmcr.2024.100636. eCollection 2024 Mar.

Authors

Laman Rahimli^{1

2

3}, Jon Salmanton-García^{1

2

3}, Philipp Kasper⁴, Michaela Simon⁵, Oliver A Cornely^{1

2

3

6}, Jannik Stemler^{1

2

3}

Affiliations

¹ Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany.
² Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), University Hospital Cologne, Faculty of Medicine), University of Cologne, Cologne, Germany.
³ German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
⁴ Department of Gastroenterology and Hepatology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
⁵ Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine, University Hospital of Cologne, University of Cologne, 50937, Cologne, Germany.
⁶ Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Abstract

We report on a 64-year-old man with necrotizing pancreatitis related, invasive candidiasis, and candidemia. Despite a multidisciplinary management including antifungal therapy, endoscopic interventions and surgery, the patients' infection progressed and lead to colon perforation, retroperitoneal abscess formation, and polymicrobial bloodstream infections. Resistance to echinocandins in Candida glabrata further complicated the course. This report emphasizes the need for vigilant monitoring and exploring alternative therapeutic approaches for patients in critical conditions.

Keywords: Candida albicans; Candida glabrata; Critical care; Echinocandin-resistance; Necrotizing pancreatitis.

Publication types

Case Reports