Copper is a trace element essential for the maintenance of normal physiological functions in cardiovascular system, and its transport and metabolisms are regulated by various copper proteins such as copper-based enzymes, copper chaperones and copper transporters. The disturbance of copper level or abnormal expression of copper proteins are closely associated with the development of cardiovascular diseases such as atherosclerosis, hypertension, ischemic heart disease, myocardial hypertrophy and heart failure. Thus, intervention of copper ion signaling pathways is expected to be an effective measure for treating cardiovascular diseases. Some copper complexes, such as trientine, copper-aspirinate complex and copper (II) diethyldithiocarbamate, have been found to play a role in the prevention and treatment of cardiovascular diseases and possess potential prospects. Exploring the role of copper in maintaining normal cardiovascular status and the potential application of copper complexes in the treatment of cardiovascular diseases may lay a foundation for finding new targets for prevention and treatment of various cardiovascular diseases, and provide new ideas for clinical treatment of cardiovascular diseases.
铜是维持心血管系统正常生理功能所必需的微量元素，其代谢和转运受到多种铜蛋白调控，包括铜基酶、铜伴侣和铜转运体等。铜水平紊乱或铜蛋白表达异常与动脉粥样硬化、高血压、缺血性心脏病、心肌肥厚和心力衰竭等心血管疾病发生和发展密切相关。因此，干预铜离子信号通路有望成为治疗心血管疾病的有效手段。目前已发现某些铜复合物，如曲恩汀、铜-阿司匹林复合物和二乙基二硫代氨基甲酸铜(II)等，在心血管疾病的防治中发挥作用，具有潜在的应用前景。探讨铜在维持心血管正常状态中的重要作用及铜复合物在治疗心血管疾病中的潜在应用，可为寻找多种心血管疾病防治新靶点奠定基础，为临床治疗心血管疾病提供新思路。.
Keywords: cardiovascular diseases; copper; copper chaperones; copper complexes; copper transporters; copper-based enzymes.