Giving birth after fertility-sparing treatment for primary leiomyosarcoma of the fallopian tube

J Obstet Gynaecol Res. 2024 Jun;50(6):1051-1055. doi: 10.1111/jog.15919. Epub 2024 Feb 29.

Abstract

Primary leiomyosarcoma of the fallopian tube (PLFT) is an extremely rare gynecological malignancy that has only been described in case reports. Fertility-sparing treatment for PLFT has not been reported previously. A 24-year-old nulligravida woman was diagnosed with stage IC1 PLFT in the right fallopian tube after experiencing right lower quadrant pain for 2 weeks. She underwent laparoscopic right salpingectomy to preserve fertility followed by adjuvant chemotherapy with gemcitabine/docetaxel. She subsequently became pregnant spontaneously, delivering a term baby 27 months after treatment. This appears to be the only report of the use of fertility-preserving treatment for PLFT. The success of the treatment provides valuable information on the preservation of fertility in young women with PLFT.

Keywords: case report; fallopian tube; fertility‐sparing; leiomyosarcoma; pregnancy and delivery.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Docetaxel / administration & dosage
  • Docetaxel / therapeutic use
  • Fallopian Tube Neoplasms* / drug therapy
  • Fallopian Tube Neoplasms* / surgery
  • Female
  • Fertility Preservation* / methods
  • Humans
  • Leiomyosarcoma* / drug therapy
  • Leiomyosarcoma* / surgery
  • Pregnancy
  • Salpingectomy
  • Young Adult

Substances

  • Docetaxel