Enhancing in vitro photothermal therapy using plasmonic gold nanorod decorated multiwalled carbon nanotubes

Fatma Oudjedi; Seung Soo Lee; Miltiadis Paliouras; Mark Trifiro; Andrew G Kirk

doi:10.1364/BOE.504746

Enhancing in vitro photothermal therapy using plasmonic gold nanorod decorated multiwalled carbon nanotubes

Biomed Opt Express. 2023 Nov 30;14(12):6629-6643. doi: 10.1364/BOE.504746. eCollection 2023 Dec 1.

Authors

Fatma Oudjedi¹, Seung Soo Lee^{2

3}, Miltiadis Paliouras^{3

4

5}, Mark Trifiro^{2

3

4}, Andrew G Kirk¹

Affiliations

¹ Department of Electrical and Computer Engineering, McGill University, Montreal, QC, Canada.
² Lady Davis Institute for Medical Research - Jewish General Hospital, Montreal, QC, Canada.
³ Division of Experimental Medicine, McGill University, Montreal, QC, Canada.
⁴ Department of Medicine, McGill University, Montreal, QC, Canada.
⁵ Guzzo Nano Research Corp, Terrebonne, QC, Canada.

Abstract

Photothermal therapy (PTT) is a promising approach for cancer treatment that selectively heats malignant cells while sparing healthy cells. Here, the light-to-heat conversion efficiency of multiwalled carbon nanotubes (MWCNTs) within the near-infrared biological transmission window is enhanced by decorating them with plasmonic gold nanorods (GNRs). The results reveal a significant photothermal enhancement of hybrid MWCNTs-GNRs compared to bare MWCNTs, displaying a 4.9 enhancement factor per unit mass. The enhanced plasmonic PTT properties of MWCNTs-GNRs are also investigated in vitro using PC3 prostate cancer cell lines, demonstrating a potent ablation efficiency. These findings advance innovative hybrid plasmonic nanostructures for clinical applications.