Safety and efficacy of early versus late removal of LAMS for pancreatic fluid collections

Philippe Willems; Eslam Esmail; Sarto Paquin; Anand Sahai

doi:10.1055/a-2226-0840

Safety and efficacy of early versus late removal of LAMS for pancreatic fluid collections

Endosc Int Open. 2024 Feb 28;12(2):E317-E323. doi: 10.1055/a-2226-0840. eCollection 2024 Feb.

Authors

Philippe Willems^{1

2}, Eslam Esmail^{2

3}, Sarto Paquin^{1

2}, Anand Sahai^{1

2}

Affiliations

¹ Gastroenterology, University of Montreal Hospital Centre, Montréal, Canada.
² Gastroenterology, CRCHUM, Montreal, Canada.
³ Tropical medicine, Tanta University Faculty of Medicine, Tanta, Egypt.

Abstract

Background and study aims Optimal timing for removal of lumen-apposing metal stents (LAMS) for effective drainage of pancreatic fluid collections (PFC) while minimizing adverse events (AE) is unknown. Outcomes of early (≤ 4 weeks) or delayed (> 4 weeks) LAMS removal on both clinical efficacy and the incidence of AE were assessed. Patients and methods This was a retrospective analysis of a prospectively maintained registry of PFC drainage between November 2016 and September 2021. Clinical success was defined as a 75% decrease in fluid collection volume with no need for reintervention at 6 months. AE were defined using the American Society for Gastrointestinal Endoscopy lexicon. Multiple logistic regression analysis was performed to determine variables associated with clinical success and AE. Results A total of 108 consecutive PFCs were included. LAMS deployment was technically successful in 103 of 108 cases (95.4%). Failure was associated with collection diameter ≤ 4 cm (odds ratio [OR] 24.0, P = 0.005) and presence of more than 50% necrotic material (OR 20.1, P = 0.01). Stents were left in place for a median of 48 days. Patients with early stent removal (< 4 weeks) had clinical success in 70.0% of cases, which was significantly less than in the group with delayed stent removal (96.4%, P = 0.03). On multiple regression analysis, clinical failure was associated with early stent removal (OR 25.5, P = 0.003). AEs occurred in 8.7% of cases (9/103). There were no predictors of AE. Notably, delayed stent removal did not predict the occurrence of AE. Conclusions Early LAMS removal (< 4 weeks) did not prevent AEs but did lead to increased clinical failure.

Keywords: Endoscopic ultrasonography; Intervention EUS; Pancreas; Performance and complications; Quality and logistical aspects.

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