The effect of pentoxifylline and different types of exercise training on coagulation factors in a rat endometriosis model

Zahra Salehpoor; Mohamad Rezapourmoghadam; Nader Tanideh; Maryam Koushkie Jahromi

doi:10.1016/j.eurox.2024.100292

The effect of pentoxifylline and different types of exercise training on coagulation factors in a rat endometriosis model

Eur J Obstet Gynecol Reprod Biol X. 2024 Feb 21:21:100292. doi: 10.1016/j.eurox.2024.100292. eCollection 2024 Mar.

Authors

Zahra Salehpoor¹, Mohamad Rezapourmoghadam¹, Nader Tanideh², Maryam Koushkie Jahromi¹

Affiliations

¹ Department of Sport Sciences, School of Education and Psychology, Shiraz University, Shiraz, Iran.
² Stem Cells Technology Research Center, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Iran.

Abstract

Objectives: This study evaluated the effects of high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), and pentoxifylline (PTX) on coagulation factors, including the amount and percentage of lymphocytes, PLC, PLR, aPTT, PT, PT.I.N. R in a model of rats with endometriosis.

Methods: Endometriosis was surgically induced in female Sprague-Dawley rats. The rats with confirmed endometrial implants were divided into control, MICT, pentoxifylline (D), HIIT+D, and MICT+D, HIIT groups. D and exercise interventions were performed for eight weeks. Then, the macroscopic size of endometriosis lesions was measured, and inflammatory factors (count and percentage of lymphocytes) and coagulation factors, including PLC, PLR, aPTT, PT, PT.I.N. R, and PLR in blood samples were evaluated.

Results: D significantly decreased the volume of lesions and significantly increased PT and PT.I.N. R in blood. HIIT decreased the volume of lesions and significantly increased PT. MICT did not cause significant effects on the target variables. MICT+D decreased the volume of lesions. HIIT+D significantly decreased the volume of lesions and PLC and increased aPTT as well as the count and percentage of lymphocytes, PT, and PT.I.N. R, and decreased PLR.

Conclusions: All interventions(except for MICT) especially HIIT+D and D by priority, induced a significant effect on reducing some indices of inflammation and coagulation.

Keywords: Coagulation; Endometriosis; High-intensity interval training; Moderate intensity continuous training; Pentoxifylline.