Applications of Graphene Field Effect Biosensors for Biological Sensing

Kiana Aran; Brett Goldsmith; Maryam Moarefian

doi:10.1007/10_2024_252

Applications of Graphene Field Effect Biosensors for Biological Sensing

Adv Biochem Eng Biotechnol. 2024 Feb 29. doi: 10.1007/10_2024_252. Online ahead of print.

Authors

Kiana Aran^{1

2

3

4

5}, Brett Goldsmith⁶, Maryam Moarefian⁷

Affiliations

¹ Shu Chien-Gene Lay Department of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA, USA. karan@ucsd.edu.
² Division of Geriatrics, Gerontology and Palliative Care, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA. karan@ucsd.edu.
³ Center for Technologies for Healthy Aging, Institute of Engineering and Medicine, University of California, San Diego, La Jolla, CA, USA. karan@ucsd.edu.
⁴ Paragraf, Somersham, UK. karan@ucsd.edu.
⁵ CRISPR QC, San Diego, CA, USA. karan@ucsd.edu.
⁶ Paragraf, Somersham, UK.
⁷ University of California, Santa Cruz, CA, USA.

PMID: 38418581
DOI: 10.1007/10_2024_252

Abstract

This chapter provides a comprehensive overview of the principles, applications, and advancements in graphene field-effect transistor (gFET) biosensors for biological sensing. The unique properties of graphene that make it ideal for biosensing, including its high conductivity, chemical stability, and ability to facilitate label-free detection, will be discussed. The chapter also explores various applications of gFET biosensors, from detecting pH and salinity changes to complex protein-protein interactions and DNA/RNA sensing. It also addresses the challenges and future directions in gFET biosensor technology, emphasizing the need for scalable manufacturing, sophisticated surface chemistry, and the integration of multiomics approaches to enhance biosensing capabilities.

Keywords: CRISPR; Field effect Biosesnors; Mutiomics.