Acute sensorimotor paraneoplastic neuropathy in a patient with small cell prostate cancer

BMJ Case Rep. 2024 Feb 27;17(2):e258380. doi: 10.1136/bcr-2023-258380.

Abstract

The authors describe a patient with a background of metastatic small cell prostate cancer who presented with a rapidly evolving sensorimotor neuropathy with bulbar features closely resembling Guillain-Barré syndrome, with a good initial response to intravenous immunoglobulins and platinum-based chemotherapy. This represented a likely paraneoplastic manifestation of the patient's urological malignancy.

Keywords: Peripheral nerve disease; Prostate Cancer.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies
  • Carcinoma, Small Cell* / complications
  • Carcinoma, Small Cell* / drug therapy
  • Guillain-Barre Syndrome* / drug therapy
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Male
  • Paraneoplastic Polyneuropathy* / diagnosis
  • Paraneoplastic Polyneuropathy* / etiology
  • Peripheral Nervous System Diseases* / drug therapy
  • Prostatic Neoplasms* / complications
  • Prostatic Neoplasms* / drug therapy

Substances

  • Autoantibodies
  • Immunoglobulins, Intravenous